[ evaluation of correlation between plasma level of CRP and WBC with ischemic stroke severity and infarct volume]

Stroke is one of the important causes of death. However the prognostic factors are not clearly defined. There are many evidences which show the role of inflammatory factors during the progression of stroke but the relation of CRP and stroke is still vague. This study was designed to determine the relation between CPR Level and WBS with severity of stroke [according to CNSS score] and volume of infarct in stroke patients. This is a cross sectional study performed during the winter and spring of 2007 on 49 patients with stroke hospitalized in Vali-e-Asr hospital of Arak. Clinical examination was done by using CNSS scoring. The CRP and WBC were measured in the first 72 hour of onset of the disease. The CT scanning together with infarct volume estimation was performed at the same time. There was no correlation between the volume of infarct with CRP serum level [r=-0.14, p=0.39] and WBC [r=-0.17, p=0.92. Also there was no correlation between CNSS score with CRP level [r=-0.04, p=0.81] and WBC [r=-0.124, p=0.40] too, but there was a significant correlation between CNSS score and stroke volume in brain CT scan [r=-0.43, p=0.006]. According to data in this study there was no correlation between serum acute phase reactant, the volume and severity of infarction

Comparing the oxidative stress indexes of CVA patients with control group

In the recent years, oxidative stress was attended as one of the causal factors of ischemic stroke. In terms of the role of genetic, geographic and ethnic factors in the prevalence of stroke, This study was designed to compare the oxidative stress indexes of stroke patients with normal healthy subjects in this geographic area. In this case-control study, 36 patients older than 50 years with ischemic stroke and 45 healthy subjects with same age and sex, were enrolled. Five milliliter blood were drawn from all subjects. Samples were centrifuged and plasma was separated. Total antioxidant capacity, lipid peroxidation and thiol levels were measured respettively by FRAP, TEA and HU methods. Then the result was analyzed using t-test. Results showed total antioxidant capacity and thiol plasma levels were lower in stroke patients in compare to healthy subjects, but only the thiol group had significant difference [P = 0/001]. Although lipid peroxidation showed a slight but non-significant difference in stroke patients in compare to control group. These findings suggest oxidative stress in patients with acute ischemic stroke may be conseaqence of an imbalance in oxidant/antioxidant homeostasis. Therefore it may be useful to recommend antioxidant medications or diet for these patients